Principal Proposed Uses
What is Citrus aurantium Used for Today?
Interactions You Should Know About
- Drugs in the MAO inhibitor family: Do not use Citrus aurantium at all.
- Ephedrine, pseudoephedrine (Sudafed), Ritalin, cyclosporine , calcium channel blockers, drugs that cause photosensitivity (such as sulfa antibiotics ), or any medication that is critical to your health: Do not use Citrus aurantium without consulting a physician.
1 Colker CM, Kalman DS, Torina GC, et al. Effects of Citrus aurantium extract, caffeine, and St. John's wort on body fat loss, lipid levels, and mood states in overweight healthy adults. Curr Ther Res . 1999;60:145–153.
2 Hedrei P, Gougeon R. Thermogenic effect of beta-sympathicomimetic compounds extracted from Citrus aurantium . McGill Nutrition and Food Science Center, Royal Victoria Hospital. 1997.
3 Kim KW, Kim HD, Jung JS, et al. Characterization of antidepressant-like effects of p-synephrine stereoisomers. Naunyn Schmiedebergs Arch Pharmacol . 2001;364:21–6.
4 Song DK, Suh HW, Jung JS, Wie MB, Son KH, Kim YH. Antidepressant-like effects of p-synephrine in mouse models of immobility tests. Neurosci Lett . 1996;23;214:107–10.
5 Miyazawa M, Okuno Y, Fukuyama M, Nakamura S, Kosaka H. Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium . J Agric Food Chem . 1999;47:5239-44.
6 Satoh Y, Tashiro S, Satoh M, Fujimoto Y, Xu JY, Ikekawa T. Studies on the bioactive constituents of Aurantii Fructus Immaturus. Yakugaku Zasshi . 1996;116:244–50.
7 Kim DH, Song MJ, Bae EA, Han MJ. Inhibitory effect of herbal medicines on rotavirus infectivity. Biol Pharm Bull . 2000;23:356–8.
8 Carvalho-Freitas MI, Costa M. Anxiolytic and sedative effects of extracts and essential oil from Citrus aurantium L. Biol Pharm Bull . 2002;25:1629–33.
9 Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother . 2004;38:812–6.
10 Edwards DJ, Fitzsimmons ME, Schuetz EG, et al. 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein. Clin Pharmacol Ther . 1999;65:237–44.
11 Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice–felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther . 2001;69:14–23.
12 Hou YC, Hsiu SL, Tsao CW, Wang YH, Chao PD. Acute intoxication of cyclosporin caused by coadministration of decoctions of the fruits of Citrus aurantium and the Pericarps of Citrus grandis . Planta Med . 2000;66:653–5.
13 Malhotra S, Bailey DG, Paine MF, Watkins PB. Seville orange juice-felodipine interaction: comparison with dilute grapefruit juice and involvement of furocoumarins. Clin Pharmacol Ther . 2001;69:14–23.
14 Bouchard NC, Howland MA, Greller HA et al. Ischemic stroke associated with use of an ephedra-free dietary supplement containing synephrine. Mayo Clin Proc . 2005;80:541-5.
15 Bui LT, Nguyen DT, Ambrose PJ. Blood Pressure and Heart Rate Effects Following a Single Dose of Bitter Orange. Ann Pharmacother . 2006;40:53-57.
- Reviewer: EBSCO CAM Review Board
- Review Date: 09/2014 -
- Update Date: 09/18/2014 -